Distribution of pilus islands in Streptococcus agalactiae that cause human infections: insights into evolution and implication for vaccine development.
نویسندگان
چکیده
At least one pilus island, PI-1 (70%), PI-2a (79%), or PI-2b (21%), was found among 898 Streptococcus agalactiae (group B streptococcus [GBS]) isolates recovered from humans, supporting the use of pilus proteins in vaccines. The stability and dominance of PI-1 and PI-2a in multiple serotypes and founder multilocus sequence types disseminated worldwide suggest it could be the PI combination present in ancestral GBS human pathogens.
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ورودعنوان ژورنال:
- Clinical and vaccine immunology : CVI
دوره 20 2 شماره
صفحات -
تاریخ انتشار 2013